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CEREBROSPINAL FLUID-INTRACRANIAL VOLUME RATIO MEASUREMENTS IN PATIENTS WITH HIV-INFECTION - CLASS IMAGE-ANALYSIS TECHNIQUE.
879 - 886.
PURPOSE: To prospectively study the Cerebrospinal fluid volume-total intracranial volume ratio (CSF/ICV) in human immunodeficiency virus (HIV)-infected patients at various stages of disease.MATERIALS AND METHODS: A total of 258 volume measurements were obtained with use of a 1.5-T magnetic resonance (MR) imager and the cluster localized automated spherical segmentation technique (which reduces two-dimensional pixel data from dual spin-echo MR images to a one-dimensional histogram) in 69 control subjects and 189 HIV-infected patients.RESULTS: The CSF/ICV was statistically significantly increased in patients with late-stage (Centers for Disease Control and Prevention group IV) acquired immunodeficiency syndrome (AIDS) (0.16 +/- 0.05 [standard deviation]) compared with seronegative control subjects (0.12 +/- 0.03) and patients without symptoms (0.13 +/- 0.03).CONCLUSION: No substantial change in CSF/ICV occurs until development of late-stage AIDS.
|Title:||CEREBROSPINAL FLUID-INTRACRANIAL VOLUME RATIO MEASUREMENTS IN PATIENTS WITH HIV-INFECTION - CLASS IMAGE-ANALYSIS TECHNIQUE|
|Keywords:||ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), 10.2068, BRAIN, 10.2068, BRAIN, ATROPHY, 10.2068, MAGNETIC RESONANCE (MR), VOLUME MEASUREMENT, 10.12146, NEURONAL LOSS, BRAIN, INDIVIDUALS, SEQUENCE, ATROPHY, AIDS|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
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