PALEY, MNJ and CHONG, WK and WILKINSON, ID and SHEPHERD, JK and CLEWS, AM and SWEENEY, BJ and HALLCRAGGS, MA and KENDALL, BE and NEWMAN, SP and HARRISON, MJG (1994) CEREBROSPINAL FLUID-INTRACRANIAL VOLUME RATIO MEASUREMENTS IN PATIENTS WITH HIV-INFECTION - CLASS IMAGE-ANALYSIS TECHNIQUE. RADIOLOGY , 190 (3) 879 - 886.
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PURPOSE: To prospectively study the Cerebrospinal fluid volume-total intracranial volume ratio (CSF/ICV) in human immunodeficiency virus (HIV)-infected patients at various stages of disease.MATERIALS AND METHODS: A total of 258 volume measurements were obtained with use of a 1.5-T magnetic resonance (MR) imager and the cluster localized automated spherical segmentation technique (which reduces two-dimensional pixel data from dual spin-echo MR images to a one-dimensional histogram) in 69 control subjects and 189 HIV-infected patients.RESULTS: The CSF/ICV was statistically significantly increased in patients with late-stage (Centers for Disease Control and Prevention group IV) acquired immunodeficiency syndrome (AIDS) (0.16 +/- 0.05 [standard deviation]) compared with seronegative control subjects (0.12 +/- 0.03) and patients without symptoms (0.13 +/- 0.03).CONCLUSION: No substantial change in CSF/ICV occurs until development of late-stage AIDS.
|Title:||CEREBROSPINAL FLUID-INTRACRANIAL VOLUME RATIO MEASUREMENTS IN PATIENTS WITH HIV-INFECTION - CLASS IMAGE-ANALYSIS TECHNIQUE|
|Keywords:||ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), 10.2068, BRAIN, 10.2068, BRAIN, ATROPHY, 10.2068, MAGNETIC RESONANCE (MR), VOLUME MEASUREMENT, 10.12146, NEURONAL LOSS, BRAIN, INDIVIDUALS, SEQUENCE, ATROPHY, AIDS|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)|
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
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