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Gadobenate dimeglumine-enhanced MRI of the breast: analysis of dose response and comparison with gadopentetate dimeglumine.

Knopp, MV; Bourne, MW; Sardanelli, F; Wasser, MN; Bonomo, L; Boetes, C; ... Spinazzi, A; + view all (2003) Gadobenate dimeglumine-enhanced MRI of the breast: analysis of dose response and comparison with gadopentetate dimeglumine. AJR Am J Roentgenol , 181 (3) 663 - 676. 10.2214/ajr.181.3.1810663.

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Abstract

The purpose of this study was to evaluate the clinical efficacy and dose response relationship of three doses of gadobenate dimeglumine for MRI of the breast and to compare the results with those obtained after a dose of 0.1 mmol/kg of body weight of gadopentetate dimeglumine. SUBJECTS AND METHODS. Gadobenate dimeglumine at 0.05, 0.1, or 0.2 mmol/kg of body weight or gadopentetate dimeglumine at 0.1 mmol/kg of body weight was administered by IV bolus injection to 189 patients with known or suspected breast cancer. Coronal three-dimensional T1-weighted gradient-echo images were acquired before and at 0, 2, 4, 6, and 8 min after the administration of the dose. Images were evaluated for lesion presence, location, size, morphology, enhancement pattern, conspicuity, and type. Lesion signal intensity-time curves were acquired, and lesion matching with on-site final diagnosis was performed. A determination of global lesion detection from unenhanced to contrast-enhanced and combined images was performed, and evaluations were made of the diagnostic accuracy for lesion detection and characterization. A full safety evaluation was conducted.

Type:Article
Title:Gadobenate dimeglumine-enhanced MRI of the breast: analysis of dose response and comparison with gadopentetate dimeglumine.
Location:United States
DOI:10.2214/ajr.181.3.1810663
Language:English
Keywords:Adult, Aged, Aged, 80 and over, Breast Neoplasms, Contrast Media, Dose-Response Relationship, Drug, Double-Blind Method, Female, Gadolinium DTPA, Humans, Injections, Intravenous, Magnetic Resonance Imaging, Meglumine, Middle Aged, Organometallic Compounds, Reproducibility of Results, Sensitivity and Specificity, Severity of Illness Index, Time Factors
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)

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