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Short echo time proton spectroscopy of the brain in HIV infection/AIDS.

Paley, M; Wilkinson, ID; Hall-Craggs, MA; Chong, WK; Chinn, RJ; Harrison, MJ; (1995) Short echo time proton spectroscopy of the brain in HIV infection/AIDS. Magn Reson Imaging , 13 (6) 871 - 875.

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Abstract

Short echo time proton spectra have been acquired from the brains of 30 male homosexual Acquired Immunodeficiency Syndrome (AIDS) patients and 12 age-matched control subjects on a 1.5 T MR system. The acquisition protocol used stimulated acquisition voxel localisation with a voxel size of 8 ml and repeat, echo, and mixing times of 5000, 20, and 30 ms, respectively. A single 25.6-ms Gaussian water suppression pulse was used with 128 spectral acquisitions and the data were eddy current corrected using a water reference. Baseline-corrected spectra were nonlinearly least squares fitted to a model function consisting of Gaussian functions representing the major metabolites reported in short echo proton spectra. Results indicate that the N-acetyl/creatine (NA/Cr) ratio is significantly reduced by 20% in AIDS patients [NA/Cr = 1.91 (0.51)] compared to control subjects [NA/Cr = 2.37 (0.25)] at short echo times.

Type:Article
Title:Short echo time proton spectroscopy of the brain in HIV infection/AIDS.
Location:UNITED STATES
Language:English
Keywords:AIDS Dementia Complex, Adult, Brain, Humans, Magnetic Resonance Spectroscopy, Male
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)

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