Ralleigh, G; Walker, AE; Hall-Craggs, MA; Lakhani, SR; Saunders, C; (2001) MR imaging of the skin and nipple of the breast: differentiation between tumour recurrence and post-treatment change. Eur Radiol , 11 (9) 1651 - 1658.
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Contrast-enhanced MR imaging of the breast has been found to be valuable in the assessment of local recurrence of previously treated breast cancer. We looked specifically at the appearances of the skin and nipple of the treated breast in order to describe the appearances of post-treatment change and recurrence in this region. Thirty-nine women treated for breast cancer had MR imaging of one or both breasts reviewed retrospectively with particular attention to the nipple and skin. The skin and chest wall were assessed for patients with mastectomies. All available histology of the skin and/or nipple, obtained following MR imaging, was reviewed. In patients who did not undergo surgery following MR imaging, clinical follow-up was obtained. Six of 39 cases had nodular enhancing areas seen on MR imaging, which correlated with histology demonstrating tumour recurrence within the skin and/or nipple. Of the remaining 33 patients, changes of linear or diffuse enhancement were seen in the skin and/or nipple of 15 patients. These changes were shown to be benign post-treatment changes at surgery/biopsy in 4 cases or by clinical follow-up in the remainder. In this article we demonstrate differing patterns of contrast enhancement within the skin and nipple in recurrent breast carcinoma vs. post-treatment changes. This suggests that contrast-enhanced MR imaging of the breast may be a useful tool in differentiating tumour recurrence from post-treatment changes within the skin and nipple.
|Title:||MR imaging of the skin and nipple of the breast: differentiation between tumour recurrence and post-treatment change.|
|Keywords:||Adenocarcinoma, Mucinous, Adult, Aged, Aged, 80 and over, Breast, Breast Neoplasms, Carcinoma, Ductal, Breast, Carcinoma, Intraductal, Noninfiltrating, Carcinoma, Lobular, Chemotherapy, Adjuvant, Combined Modality Therapy, Humans, Image Enhancement, Magnetic Resonance Imaging, Mastectomy, Middle Aged, Neoplasm Invasiveness, Neoplasm Recurrence, Local, Nipples, Radiotherapy, Adjuvant, Retrospective Studies, Sensitivity and Specificity, Skin, Skin Neoplasms|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)|
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