UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

DNA vaccination: a potential weapon against infection and cancer.

Stevenson, FK; Rosenberg, W; (2001) DNA vaccination: a potential weapon against infection and cancer. Vox Sang , 80 (1) pp. 12-18.

Full text not available from this repository.


DNA vaccination is a novel approach for inducing immunity against target antigens. It provides a direct link between identification of genes encoding these antigens and incorporation of the gene sequences into a vaccine vehicle. Identification of candidate genes is proceeding very rapidly both for infectious organisms and for cancer cells. One advantage is that DNA appears to activate all pathways of immunity, especially cytotoxic T-cell responses, which have been difficult to induce with protein vaccines. For viruses, including those which have caused problems for blood transfusion, DNA vaccination could be used for prevention. However, for chronic infection, or for cancer, vaccination will be performed in a therapeutic setting. For this situation, it is probable that immune-activating sequences will have to be included in the vaccine. The ease of manipulation of gene sequences, together with the increasing knowledge of the operation of the immune system, means that we now have the tools to take vaccines into the next exciting stage of development.

Type: Article
Title: DNA vaccination: a potential weapon against infection and cancer.
Location: England
Keywords: Animals, Antibody Formation, Antigen Presentation, Antigens, Biological Assay, Blood Transfusion, Cancer Vaccines, Cytokines, Cytotoxicity, Immunologic, Genes, Synthetic, Hepacivirus, Hepatitis C, Hepatitis C Antigens, Humans, Immunotherapy, Active, Infection, Infection Control, Mice, Mice, Transgenic, Models, Animal, Models, Immunological, Neoplasms, Pan troglodytes, T-Lymphocytes, Cytotoxic, Vaccines, DNA, Vaccines, Synthetic, Viral Hepatitis Vaccines
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/1340664
Downloads since deposit
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item