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CD44 isoform expression on colonic epithelium mediates lamina propria lymphocyte adhesion and is controlled by Th1 and Th2 cytokines.

Macdonald, DC; Leir, SH; Brooks, C; Sanders, E; Lackie, P; Rosenberg, W; (2003) CD44 isoform expression on colonic epithelium mediates lamina propria lymphocyte adhesion and is controlled by Th1 and Th2 cytokines. Eur J Gastroenterol Hepatol , 15 (10) 1101 - 1110. 10.1097/01.meg.0000085473.12407.00.

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Abstract

CD44v6 and CD44v3 are expressed on the surface of colonic epithelial cells in ulcerative colitis to a much greater extent than in Crohn's disease. We investigated mediators that induce CD44v6 and CD44v3 expression on colonic epithelium and the potential role of CD44 in mediating leucocyte-epithelial adhesion.

Type:Article
Title:CD44 isoform expression on colonic epithelium mediates lamina propria lymphocyte adhesion and is controlled by Th1 and Th2 cytokines.
Location:England
DOI:10.1097/01.meg.0000085473.12407.00
Language:English
Keywords:Antigens, CD44, Basement Membrane, Cell Adhesion, Colitis, Ulcerative, Colon, Cytokines, Glycoproteins, HT29 Cells, Humans, Inflammatory Bowel Diseases, Interleukin-13, Interleukin-4, Intestinal Mucosa, Th1 Cells, Th2 Cells, Up-Regulation

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