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Role of a cirrhosis risk score for the early prediction of fibrosis progression in hepatitis C patients with minimal liver disease.

Trépo, E; Potthoff, A; Pradat, P; Bakshi, R; Young, B; Lagier, R; Moreno, C; (2011) Role of a cirrhosis risk score for the early prediction of fibrosis progression in hepatitis C patients with minimal liver disease. J Hepatol , 55 (1) pp. 38-44. 10.1016/j.jhep.2010.10.018.

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Abstract

Fibrosis progression in patients with chronic hepatitis C (CHC) is highly variable. A Cirrhosis Risk Score (CRS) based on seven genetic variants has been recently developed for identifying patients at risk for cirrhosis. The objective of this study was to assess the role of the CRS for the early prediction of fibrosis progression in CHC patients with mild liver fibrosis. In addition, we evaluated the potential benefit, for prediction accuracy, of a recently described non-invasive fibrosis staging assay, the Enhanced Liver Fibrosis (ELF) test.

Type: Article
Title: Role of a cirrhosis risk score for the early prediction of fibrosis progression in hepatitis C patients with minimal liver disease.
Location: England
DOI: 10.1016/j.jhep.2010.10.018
Keywords: Cohort Studies, Disease Progression, Female, Genetic Variation, Hepatitis C, Chronic, Humans, Liver Cirrhosis, Male, Middle Aged, Multivariate Analysis, Polymorphism, Single Nucleotide, Retrospective Studies, Risk Factors
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)
URI: http://discovery.ucl.ac.uk/id/eprint/1340635
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