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Randomized clinical trial: a pilot study investigating the safety and effectiveness of an escalating dose of peginterferon α-2a monotherapy for 48 weeks compared with standard clinical care in patients with hepatitis C cirrhosis.

Tanwar, S; Wright, M; Foster, GR; Ryder, SD; Mills, PR; Cramp, ME; Parkes, J; (2012) Randomized clinical trial: a pilot study investigating the safety and effectiveness of an escalating dose of peginterferon α-2a monotherapy for 48 weeks compared with standard clinical care in patients with hepatitis C cirrhosis. Eur J Gastroenterol Hepatol , 24 (5) pp. 543-550. 10.1097/MEG.0b013e3283513e69.

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Abstract

A substantial proportion of patients with chronic hepatitis C virus (HCV) cirrhosis fail to eradicate infection and develop liver-related complications. Despite evidence that interferon-α has an antifibrotic effect, clinical trials have demonstrated that low-dose maintenance interferon does not improve outcomes in patients with compensated HCV cirrhosis following a lead-in phase of interferon. In a pilot study, we have investigated the efficacy of an escalating dose of pegylated interferon α-2a (PEG-IFN2a) as compared with standard clinical care in patients with more advanced HCV Child's A or B cirrhosis without a lead-in phase.

Type: Article
Title: Randomized clinical trial: a pilot study investigating the safety and effectiveness of an escalating dose of peginterferon α-2a monotherapy for 48 weeks compared with standard clinical care in patients with hepatitis C cirrhosis.
Location: England
DOI: 10.1097/MEG.0b013e3283513e69
Keywords: Adult, Antiviral Agents, Biological Markers, Dose-Response Relationship, Drug, Female, Hepatitis C, Chronic, Humans, Interferon-alpha, Kaplan-Meier Estimate, Liver Cirrhosis, Male, Middle Aged, Pilot Projects, Polyethylene Glycols, Prospective Studies, Quality of Life, Recombinant Proteins, Treatment Outcome
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)
URI: http://discovery.ucl.ac.uk/id/eprint/1340634
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