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Expression of P2X(2) and P2X (3) receptors in the rat carotid sinus, aortic arch, vena cava, and heart, as well as petrosal and nodose ganglia.

Song, X; Gao, X; Guo, D; Yu, Q; Guo, W; He, C; Burnstock, G; (2012) Expression of P2X(2) and P2X (3) receptors in the rat carotid sinus, aortic arch, vena cava, and heart, as well as petrosal and nodose ganglia. Purinergic Signal , 8 (1) 15 - 22. 10.1007/s11302-011-9249-4.

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Abstract

With single- and double-labeling immunofluorescence techniques, the distribution patterns and morphological characteristics of P2X(2)- and P2X(3)-immunoreactive nerve fiber terminals and neuronal bodies have been studied in the main circulatory system baroreceptors and the nodose and petrosal ganglia of rats. A high density of P2X(2)- and P2X(3)-immunoreactive nerve fiber terminals was detected in the carotid sinus. P2X(2)- and P2X(3)-immunoreactive nerve fiber terminals were also distributed widely in the aortic arch, atrium, vena cava, and ventricles. Almost all the P2X(2)-immunoreactive nerve fiber terminals were immunoreactive for P2X(3) receptors. P2X(2)- and P2X(3)-immunoreactive neuronal bodies were also detected in the nodose and petrosal ganglia, which are the sources of the P2X(2)- and P2X(3)-immunoreactive nerve terminals. P2X(2) and P2X(3) receptors were expressed in the same ganglionic neurons. These data indicate that extracellular ATP, via the homomeric P2X(2) and P2X(3) receptors, and heteromeric P2X(2/3) receptor in the sensory receptors of carotid sinus, aortic arch, atrium, and vena cava, may be involved in the regulation of systematic circulation blood pressure.

Type: Article
Title: Expression of P2X(2) and P2X (3) receptors in the rat carotid sinus, aortic arch, vena cava, and heart, as well as petrosal and nodose ganglia.
Location: Netherlands
DOI: 10.1007/s11302-011-9249-4
Language: English
UCL classification: UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)
URI: http://discovery.ucl.ac.uk/id/eprint/1340125
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