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A composite computational model of liver glucose homeostasis. II. Exploring system behaviour.

Sumner, T; Hetherington, J; Seymour, RM; Li, L; Varela Rey, M; Yamaji, S; ... Warner, A; + view all (2012) A composite computational model of liver glucose homeostasis. II. Exploring system behaviour. J R Soc Interface , 9 (69) 701 - 706. 10.1098/rsif.2011.0783.

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Abstract

Using a composite model of the glucose homeostasis system, consisting of seven interconnected submodels, we enumerate the possible behaviours of the model in response to variation of liver insulin sensitivity and dietary glucose variability. The model can reproduce published experimental manipulations of the glucose homeostasis system and clearly illustrates several important properties of glucose homeostasis-boundedness in model parameters of the region of efficient homeostasis, existence of an insulin sensitivity that allows effective homeostatic control and the importance of transient and oscillatory behaviour in characterizing homeostatic failure. Bifurcation analysis shows that the appearance of a stable limit cycle can be identified.

Type:Article
Title:A composite computational model of liver glucose homeostasis. II. Exploring system behaviour.
Location:England
DOI:10.1098/rsif.2011.0783
Language:English
Additional information:PMCID: PMC3284144
Keywords:Activity Cycles, Blood Glucose, Glucose, Homeostasis, Humans, Insulin, Insulin Resistance, Liver, Models, Biological, Systems Biology
UCL classification:UCL > Professional Services > Information Services Division > Research IT Services > Research Comp and Facilitating Services
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > School of BEAMS > Faculty of Engineering Science > Engineering Science Faculty Office
UCL > VP Research

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