de la Concha, EG;
de Almeida, RC;
van Diemen, CC;
Plaza Izurieta, L;
Spanish Consortium on the Genetics of Coeliac Disease (CEGEC), ;
PreventCD Study Group, ;
Wellcome Trust Case Control Consortium (WTCCC), ;
van Heel, DA;
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Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease.
1193 - 1201.
Using variants from the 1000 Genomes Project pilot European CEU dataset and data from additional resequencing studies, we densely genotyped 183 non-HLA risk loci previously associated with immune-mediated diseases in 12,041 individuals with celiac disease (cases) and 12,228 controls. We identified 13 new celiac disease risk loci reaching genome-wide significance, bringing the number of known loci (including the HLA locus) to 40. We found multiple independent association signals at over one-third of these loci, a finding that is attributable to a combination of common, low-frequency and rare genetic variants. Compared to previously available data such as those from HapMap3, our dense genotyping in a large sample collection provided a higher resolution of the pattern of linkage disequilibrium and suggested localization of many signals to finer scale regions. In particular, 29 of the 54 fine-mapped signals seemed to be localized to single genes and, in some instances, to gene regulatory elements. Altogether, we define the complex genetic architecture of the risk regions of and refine the risk signals for celiac disease, providing the next step toward uncovering the causal mechanisms of the disease.
|Title:||Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease.|
|Keywords:||Case-Control Studies, Celiac Disease, Chromosome Mapping, Gene Frequency, Genetic Loci, Genome-Wide Association Study, Haplotypes, Humans, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Risk Factors|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Genetics, Evolution and Environment > UCL Genetics Institute|
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