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Slow calcium waves and redox changes precede mitochondrial permeability transition pore opening in the intact heart during hypoxia and reoxygenation.

Davidson, SM; Yellon, DM; Murphy, MP; Duchen, MR; (2012) Slow calcium waves and redox changes precede mitochondrial permeability transition pore opening in the intact heart during hypoxia and reoxygenation. Cardiovasc Res , 93 (3) 445 - 453. 10.1093/cvr/cvr349.

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Abstract

Opening of the mitochondrial permeability transition pore (mPTP) is an important step on the pathway towards cardiomyocyte death, defining the extent of injury following cardiac ischaemia and reperfusion. In isolated mitochondria, mPTP opening is triggered by calcium overload facilitated by oxidative stress. In isolated cells, however, it has been suggested that mPTP opening occurs before calcium overload and is stimulated by oxidative stress. Our objective was to establish the events that cause mPTP opening in the intact heart.

Type:Article
Title:Slow calcium waves and redox changes precede mitochondrial permeability transition pore opening in the intact heart during hypoxia and reoxygenation.
Location:England
DOI:10.1093/cvr/cvr349
Language:English
Keywords:Animals, Anoxia, Calcium Signaling, Cell Death, Mice, Mitochondrial Membrane Transport Proteins, Mitochondrial Membranes, Myocardial Reperfusion Injury, Myocardium, Myocytes, Cardiac, Oxidation-Reduction, Perfusion, Rats
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Cell and Developmental Biology
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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