Ross, J and Gherardi, E and Mallorqui-Fernandez, N and Bocci, M and Sobkowicz, A and Rees, M and Rowe, A and Ellmerich, S and Massie, I and Soeda, J and Selden, C and Hodgson, H (2012) Protein engineered variants of hepatocyte growth factor/scatter factor promote proliferation of primary human hepatocytes and in rodent liver. Gastroenterology , 142 (4) 897 - 906. 10.1053/j.gastro.2011.12.006.
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Abstract
Hepatocyte growth factor/scatter factor (HGF/SF) stimulates hepatocyte DNA synthesis and protects against apoptosis; in vivo it promotes liver regeneration and reduces fibrosis. However, its therapeutic value is limited by its complex domain structure, high cost of production, instability, and poor tissue penetration due to sequestration by heparin sulfate proteoglycans (HSPGs).
| Type: | Article |
|---|---|
| Title: | Protein engineered variants of hepatocyte growth factor/scatter factor promote proliferation of primary human hepatocytes and in rodent liver. |
| Location: | United States |
| DOI: | 10.1053/j.gastro.2011.12.006 |
| Language: | English |
| Keywords: | Animals, Apoptosis, Binding Sites, Carbon Tetrachloride, Caspase 3, Caspase 7, Cell Proliferation, Cells, Cultured, DNA Replication, Disease Models, Animal, Dose-Response Relationship, Drug, Fas Ligand Protein, Heparan Sulfate Proteoglycans, Hepatectomy, Hepatocyte Growth Factor, Hepatocytes, Humans, Liver, Liver Cirrhosis, Liver Regeneration, Male, Mice, Mice, Inbred BALB C, Models, Molecular, Peptide Fragments, Poly(ADP-ribose) Polymerases, Protein Conformation, Protein Engineering, Protein Stability, Rats, Rats, Sprague-Dawley, Recombinant Proteins, Time Factors, Ultracentrifugation |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Inflammation UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health |
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