UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Renal failure and cirrhosis: a systematic review of mortality and prognosis.

Fede, G; D'Amico, G; Arvaniti, V; Tsochatzis, E; Germani, G; Georgiadis, D; Morabito, A; (2012) Renal failure and cirrhosis: a systematic review of mortality and prognosis. J Hepatol , 56 (4) pp. 810-818. 10.1016/j.jhep.2011.10.016.

Full text not available from this repository.

Abstract

BACKGROUND & AIMS: To evaluate renal failure (RF) in cirrhosis to determine and quantify its prognostic significance. METHODS: Studies were identified by MEDLINE, EMBASE, Cochrane, ISI Web of Science (1977-2010); search terms included renal failure, mortality, and cirrhosis. Included studies (n=74) reported >10 patients and mortality data (8088 patients). Mortality at 1, 3, and 12 months was evaluated with respect to Child-Pugh score, serum creatinine, ascites, ICU status or sepsis, prospective study design, and publication year. Pooled odds ratio (POR) for death was compared for RF vs. non-RF (5668 patients). RESULTS: Overall median mortality for RF patients was 67%: 58% at 1 month and 63% (IQR 54-79) at 12 months. POR for death RF vs. non-RF patients was 7.6 (95%CI 5.4-10.8). Overall mortality before 2005 (1264 patients) was 74% and after 2005 (2833 patients) was 63% with a marked reduction only at 30 days (71% vs. 52%). CONCLUSIONS: This study provides a measure of the increased risk of death in cirrhosis with renal failure. RF increases mortality 7-fold, with 50% of patients dying within one month. Preventative strategies for RF are needed.

Type: Article
Title: Renal failure and cirrhosis: a systematic review of mortality and prognosis.
Location: England
DOI: 10.1016/j.jhep.2011.10.016
Keywords: Comorbidity, Female, Humans, Liver Cirrhosis, Male, Middle Aged, Multivariate Analysis, Prognosis, Renal Insufficiency, Risk Factors, Severity of Illness Index, Time Factors
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)
URI: http://discovery.ucl.ac.uk/id/eprint/1335057
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item