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HIV infection of CD45RA(+) and CD45RO(+) CD4(+) T cells

Helbert, MR; Walter, J; LAge, J; Beverley, PCL; (1997) HIV infection of CD45RA(+) and CD45RO(+) CD4(+) T cells. CLIN EXP IMMUNOL , 107 (2) 300 - 305.

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Abstract

HIV preferentially infects the RO(+) memory subset of CD4(+) lymphocytes, and these cells are lost earlier in HIV infection than their RA(+) counterparts. Although both populations express similar amounts of CD4 and bind the HIV envelope glycoprotein (gp120) equally well, calcium signals and CD4 down-regulation subsequent to gp120 binding are not the same in both populations, Data suggest these disparities are mediated by differential tyrosine kinase (TK) regulation. Syncytium formation is enhanced in RO(+) cells, partly a consequence of increased leucocyte function antigen-1 (LFA-1) expression and, again, partly due to altered TK regulation. After in vitro HIV infection, reverse transcription is not detected in RA(+) cells, is minimal in the RO(+) class II- population, but progresses well in RO(+) class II+. Infection followed by mitogen stimulation permits reverse transcription in all cells. HIV infection of RO(+) cells is enhanced moderately at multiple points in the virus life cycle.

Type: Article
Title: HIV infection of CD45RA(+) and CD45RO(+) CD4(+) T cells
Keywords: HIV, syncytium, reverse transcription, CD4, CD45, IMMUNODEFICIENCY-VIRUS TYPE-1, ENVELOPE GLYCOPROTEIN, HUMAN-LYMPHOCYTES, BINDING, CD45, ACTIVATION, TYROSINE, FUSION, ABNORMALITIES, DYSFUNCTION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/1334847
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