UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Reappearance of miniature endplate potentials in frog neuromuscular junctions "silenced" by lanthanum ions.

Glavinović, MI; Lee, S; Miledi, R; (1989) Reappearance of miniature endplate potentials in frog neuromuscular junctions "silenced" by lanthanum ions. Neuroscience , 31 (1) pp. 181-186.

Full text not available from this repository.

Abstract

Miniature endplate potentials and currents were recorded from frog sartorius muscle fibres. As expected from previous work, La3+ caused a very large increase in miniature endplate potential frequency, followed by a progressive decrease, ending in the virtually complete disappearance of miniature endplate potentials. Soon after its application, La3+ caused an increase in the amplitude of miniature endplate potentials due to a lengthening of the underlying miniature endplate currents. Analysis of membrane current fluctuations produced by acetylcholine showed that La3+ caused an increase in the lifetime of the channels opened by acetylcholine. After miniature endplate potentials had vanished following La3+ treatment, the muscles were placed in organ culture conditions to see if miniature endplate potentials would reappear. After several hours miniature endplate potential activity was resumed in about 25% of the endplates, and disappeared again a few hours later, presumably because of accelerated nerve terminal degeneration. Preliminary electron microscopic observations suggest that the recovery of miniature endplate potential activity was accompanied by re-formation of synaptic vesicles in the motor endings.

Type: Article
Title: Reappearance of miniature endplate potentials in frog neuromuscular junctions "silenced" by lanthanum ions.
Location: United States
Keywords: Animals, Lanthanum, Motor Endplate, Neuromuscular Junction, Rana temporaria, Synaptic Transmission
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/133447
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item