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Phenomenological model of diffuse global and regional atrophy using finite-element methods

Camara, O.; Schweiger, M.; Scahill, R.I.; Crum, W.R.; Sneller, B.I.; Schnabel, J.A.; Ridgway, G.R.; ... Fox, N.C.; + view all (2006) Phenomenological model of diffuse global and regional atrophy using finite-element methods. IEEE Transactions on Medical Imaging , 25 (11) pp. 1417-1430. 10.1109/TMI.2006.880588. Green open access

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Abstract

The main goal of this work is the generation of ground-truth data for the validation of atrophy measurement techniques, commonly used in the study of neurodegenerative diseases such as dementia. Several techniques have been used to measure atrophy in cross-sectional and longitudinal studies, but it is extremely difficult to compare their performance since they have been applied to different patient populations. Furthermore, assessment of performance based on phantom measurements or simple scaled images overestimates these techniques' ability to capture the complexity of neurodegeneration of the human brain. We propose a method for atrophy simulation in structural magnetic resonance (MR) images based on finite-element methods. The method produces cohorts of brain images with known change that is physically and clinically plausible, providing data for objective evaluation of atrophy measurement techniques. Atrophy is simulated in different tissue compartments or in different neuroanatomical structures with a phenomenological model. This model of diffuse global and regional atrophy is based on volumetric measurements such as the brain or the hippocampus, from patients with known disease and guided by clinical knowledge of the relative pathological involvement of regions and tissues. The consequent biomechanical readjustment of structures is modelled using conventional physics-based techniques based on biomechanical tissue properties and simulating plausible tissue deformations with finite-element methods. A thermoelastic model of tissue deformation is employed, controlling the rate of progression of atrophy by means of a set of thermal coefficients, each one corresponding to a different type of tissue. Tissue characterization is performed by means of the meshing of a labelled brain atlas, creating a reference volumetric mesh that will be introduced to a finite-element solver to create the simulated deformations. Preliminary work on the simulation of acquisition artefa- - cts is also presented. Cross-sectional and l

Type: Article
Title: Phenomenological model of diffuse global and regional atrophy using finite-element methods
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/TMI.2006.880588
Publisher version: http://dx.doi.org/10.1109/TMI.2006.880588
Language: English
Additional information: ©2006 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
UCL classification: UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Neurodegenerative Diseases
URI: http://discovery.ucl.ac.uk/id/eprint/13340
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