Edirisinghe, N.A.;
(2011)
A novel wearable electronic device for treating neurogenic detrusor overactivity by conditional neuromodulation.
Masters thesis , UCL (University College London).
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Abstract
Urinary incontinence is the involuntary leakage of urine and affects one in twenty of the population across all ages leading to poor quality of life and can be very high cost to the nation. It is possible to reduce these costs by accurate diagnosis and appropriate management of the condition. Urinary incontinence is often associated with an overactive bladder or urethral sphincter weakness, or both as a result of interrupting the pathway to nervous communication between the brain and the bladder leading to uncoordinated activity in the lower urinary tract. Treatment options for overactive bladder include antimuscarinic drugs and implanted electrical stimulators. However these drugs have intolerable side effects, while implanting a stimulator is a surgical procedure which is associated with degree of risk and becomes ineffective due to habituation to the continuous stimulation. The aim of the research was to develop a novel wearable anal device designed to deliver conditional neuromodulation. The device detects the electromyography activity in the lower urinary tract, and provides the transrectal stimulation to the Pudendal nerve when required, in order to suppress the bladder contractions while contracting the urethral sphincters. The clinical study included designing and manufacturing patient compatible model and conducting a clinical study to measure the safety and the efficacy of the device. Electronics circuit design included amplifier, signal processing system and constant current stimulator based on the specification derived from the clinical study and finally focused on optimisation of the device electrodes for improving stimulating parameters.
| Type: | Thesis (Masters) |
|---|---|
| Title: | A novel wearable electronic device for treating neurogenic detrusor overactivity by conditional neuromodulation |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| UCL classification: | UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1332894 |
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