Kääb, S and Crawford, DC and Sinner, MF and Behr, ER and Kannankeril, PJ and Wilde, AA and Bezzina, CR and Schulze-Bahr, E and Guicheney, P and Bishopric, NH and Myerburg, RJ and Schott, JJ and Pfeufer, A and Beckmann, BM and Martens, E and Zhang, T and Stallmeyer, B and Zumhagen, S and Denjoy, I and Bardai, A and Van Gelder, IC and Jamshidi, Y and Dalageorgou, C and Marshall, V and Jeffery, S and Shakir, S and Camm, AJ and Steinbeck, G and Perz, S and Lichtner, P and Meitinger, T and Peters, A and Wichmann, HE and Ingram, C and Bradford, Y and Carter, S and Norris, K and Ritchie, MD and George, AL and Roden, DM (2012) A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes. Circ Cardiovasc Genet , 5 (1) 91 - 99. 10.1161/CIRCGENETICS.111.960930.
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Drug-induced long-QT syndrome (diLQTS) is an adverse drug effect that has an important impact on drug use, development, and regulation. We tested the hypothesis that common variants in key genes controlling cardiac electric properties modify the risk of diLQTS.
|Title:||A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes.|
|Additional information:||PMCID: PMC3288202|
|Keywords:||Aged, Aged, 80 and over, Alleles, Amino Acid Substitution, Anti-Arrhythmia Agents, Case-Control Studies, Cohort Studies, Female, Genotype, Haplotypes, Humans, Long QT Syndrome, Male, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Potassium, Potassium Channels, Voltage-Gated, Torsades de Pointes|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science|
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