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A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes.

Kääb, S; Crawford, DC; Sinner, MF; Behr, ER; Kannankeril, PJ; Wilde, AA; ... Roden, DM; + view all (2012) A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes. Circ Cardiovasc Genet , 5 (1) 91 - 99. 10.1161/CIRCGENETICS.111.960930.

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Abstract

Drug-induced long-QT syndrome (diLQTS) is an adverse drug effect that has an important impact on drug use, development, and regulation. We tested the hypothesis that common variants in key genes controlling cardiac electric properties modify the risk of diLQTS.

Type:Article
Title:A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes.
Location:United States
DOI:10.1161/CIRCGENETICS.111.960930
Language:English
Additional information:PMCID: PMC3288202
Keywords:Aged, Aged, 80 and over, Alleles, Amino Acid Substitution, Anti-Arrhythmia Agents, Case-Control Studies, Cohort Studies, Female, Genotype, Haplotypes, Humans, Long QT Syndrome, Male, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Potassium, Potassium Channels, Voltage-Gated, Torsades de Pointes
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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