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A mitochondrial-targeted cyclosporin A with high binding affinity for cyclophilin D yields improved cytoprotection of cardiomyocytes

Dube, H; Selwood, D; Malouitre, S; Capano, M; Simone, MI; Crompton, M; (2012) A mitochondrial-targeted cyclosporin A with high binding affinity for cyclophilin D yields improved cytoprotection of cardiomyocytes. BIOCHEMICAL JOURNAL , 441 pp. 901-907. 10.1042/BJ20111301. Gold open access

Type: Article
Title: A mitochondrial-targeted cyclosporin A with high binding affinity for cyclophilin D yields improved cytoprotection of cardiomyocytes
Open access status: An open access publication
DOI: 10.1042/BJ20111301
Keywords: Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, BIOCHEMISTRY & MOLECULAR BIOLOGY, cyclophilin D (CyP-D), cyclosporin, ischaemia, mitochondrial targeting, reperfusion injury (RI), triphenylphosphonium (TPP+), PERMEABILITY TRANSITION PORE, ISCHEMIA-REPERFUSION, CELL-DEATH, CRYSTAL-STRUCTURE, OXIDATIVE STRESS, INJURY, COMPLEXES, INVOLVEMENT, INHIBITION, PHOSPHATE
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Wolfson Inst for Biomedical Research
URI: http://discovery.ucl.ac.uk/id/eprint/1332276
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