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Polymorphisms in Dopamine System Genes Are Associated With Individual Differences in Attention in Infancy

Holmboe, K; Nemoda, Z; Fearon, RMP; Csibra, G; Sasvari-Szekely, M; Johnson, MH; (2010) Polymorphisms in Dopamine System Genes Are Associated With Individual Differences in Attention in Infancy. DEV PSYCHOL , 46 (2) 404 - 416. 10.1037/a0018180.

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Abstract

Knowledge about the functional status of the frontal cortex in infancy is limited. This study investigated the effects of polymorphisms in four dopamine system genes on performance in a task developed to assess such functioning, the Freeze-Frame task, at 9 months of age. Polymorphisms in the catechol-O-methyltransferase (COMT) and the dopamine D4 receptor (DRD4) genes are likely to impact directly on the functioning of the frontal cortex, whereas polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes might influence frontal cortex functioning indirectly via strong frontostriatal connections. A significant effect of the COMT valine(158)methionine (Val(158)Met) polymorphism was found. Infants with the Met/Met genotype were significantly less distractible than infants with the Val/Val genotype in Freeze-Frame trials presenting an engaging central stimulus. In addition, there was an interaction with the DAT1 3' variable number of tandem repeats polymorphism; the COMT effect was present only in infants who did not have two copies of the DAT1 10-repeat allele. These findings indicate that dopaminergic polymorphisms affect selective aspects of attention as early as infancy and further validate the Freeze-Frame task as a frontal cortex task.

Type: Article
Title: Polymorphisms in Dopamine System Genes Are Associated With Individual Differences in Attention in Infancy
DOI: 10.1037/a0018180
Keywords: frontal cortex, infancy, dopamine genes, attention, frontal-subcortical circuits, CATECHOL-O-METHYLTRANSFERASE, DEFICIT HYPERACTIVITY DISORDER, SEROTONIN TRANSPORTER PROMOTER, BRAIN ELECTRICAL-ACTIVITY, FRONTAL-SUBCORTICAL CIRCUITS, POSITRON EMISSION TOMOGRAPHY, HUMAN PREFRONTAL CORTEX, COMT VAL(108/158) MET, CARD SORT TEST, RECEPTOR GENE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: http://discovery.ucl.ac.uk/id/eprint/1331774
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