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Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling

Baum, B; Georgiou, M; (2011) Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling. J CELL BIOL , 192 (6) 907 - 917. 10.1083/jcb.201009141. Gold open access

Abstract

The epithelial cadherin (E-cadherin)-catenin complex binds to cytoskeletal components and regulatory and signaling molecules to form a mature adherens junction (AJ). This dynamic structure physically connects neighboring epithelial cells, couples intercellular adhesive contacts to the cytoskeleton, and helps define each cell's apical-basal axis. Together these activities coordinate the form, polarity, and function of all cells in an epithelium. Several molecules regulate AJ formation and integrity, including Rho family GTPases and Par polarity proteins. However, only recently, with the development of live-cell imaging, has the extent to which E-cadherin is actively turned over at junctions begun to be appreciated. This turnover contributes to junction formation and to the maintenance of epithelial integrity during tissue homeostasis and remodeling.

Type: Article
Title: Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling
Open access status: An open access publication
DOI: 10.1083/jcb.201009141
Publisher version: http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC30631...
Keywords: CELL-CELL ADHESION, DROSOPHILA E-CADHERIN, GTP-BINDING PROTEIN, ACTIN CYTOSKELETON, APICAL CONSTRICTION, PLASMA-MEMBRANE, DORSAL CLOSURE, ALPHA-CATENIN, BETA-CATENIN, RECYCLING ENDOSOMES
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/1331727
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