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Low-dose methotrexate in systemic onset juvenile chronic arthritis

Speckmaier, M; Findeisen, J; Woo, P; Hall, A; Sills, JA; Price, T; Hollingworth, P; ... Ansell, BM; + view all (1989) Low-dose methotrexate in systemic onset juvenile chronic arthritis. Clin.Exp.Rheumatol. , 7 (6) pp. 647-650.

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Twelve children with severe systemic juvenile chronic arthritis, all requiring high dose corticosteroids, have been admitted to a pilot study to evaluate the effect of low-dose methotrexate (mean dose: 8.5 mg/M2) on disease activity over a 6 month period. Definite improvement occurred in 4 children, allowing reduction of the steroid dose in 2 cases. Two children showed an acute flare of disease activity during the treatment period and in three, steroids had to be increased. Overall, side effects were rare with a rise in transaminases only occurring once. MTX blood levels taken on 14 occasions in 8 children documented absorption in all cases with a mean level of 3.45 x 10(-7) mol/l on a mean dose of 9 mg/M2. Low-dose MTX appears to be a safe drug in the short term treatment of severe systemic JCA with beneficial effect in about a third of patients. Long-term controlled trials will be needed to evaluate its role in the treatment of systemic disease as well as side effects

Type: Article
Title: Low-dose methotrexate in systemic onset juvenile chronic arthritis
Additional information: DA - 19900302 IS - 0392-856X LA - eng PT - Journal Article RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Glucocorticoids) RN - 59-05-2 (Methotrexate) SB - IM
Keywords: Absorption, administration & dosage, Administration,Oral, Adolescent, Anti-Inflammatory Agents, Anti-Inflammatory Agents,Non-Steroidal, Arthritis, Arthritis,Juvenile Rheumatoid, blood, Child, Child,Preschool, Drug Administration Schedule, drug therapy, Drug Therapy,Combination, Female, Glucocorticoids, Human, Male, Methotrexate, pharmacokinetics, Research, Rheumatology, Steroids
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/133160
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