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Serious hazards of transfusion (SHOT) initiative: analysis of the first two annual reports

Williamson, LM; Lowe, S; Love, EM; Cohen, H; Soldan, K; McClelland, DBL; Skacel, P; (1999) Serious hazards of transfusion (SHOT) initiative: analysis of the first two annual reports. BRIT MED J , 319 (7201) 16 - 19.

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Abstract

Objective To receive and collate reports of death or major complications of transfusion of blood or components.Design Haematologists were invited confidentially to report deaths and major complications after blood transfusion during October 1996 to September 1998. Setting Hospitals in United Kingdom and Ireland.Subjects Patients who died or experienced serious complications, as defined below; associated with transfusion of red cells, platelets, fresh frozen plasma or cryoprecipitate.Main outcome measures Death, "wrong" blood transfused to patient acute and delayed transfusion reactions, transfusion related acute lung injury, transfusion associated graft versus host disease, post-transfusion purpura, and infection transmitted by transfusion. Circumstances relating to these cases and relative frequency of complications.Results Over 24 months, 366 cases were reported of which 191 (52%) were "wrong blood to patient" episodes. Analysis of these revealed multiple errors of identification, often beginning when blood was collected from the blood bank. There were 22 deaths from all causes, including three from ABO incompatibility. There were 12 infections: four bacterial (one fatal), seven viral, and one fatal case of malaria. During die second 12 months, 164/424 hospitals (39%) submitted a "nil to report" return.Conclusions Transfusion is now extremely safe, but vigilance is needed to ensure correct identification of blood and patient Staff education should include an awareness of ABO incompatibility and bacterial contamination as causes of life threatening reactions to blood.

Type: Article
Title: Serious hazards of transfusion (SHOT) initiative: analysis of the first two annual reports
Keywords: BLOOD-TRANSFUSION, SYSTEM, RISK
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/1331449
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