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Second-trimester pregnancy loss is associated with activated C resistance (Editor’s selection: 1997 Year Book of Obstetrics and Gynaecology and selected to be abstracted in the July 1996 issue of Focus and Opinion/Obstetrics and Gynaecology).

Rai, R; Regan, L; Hadley, E; Dave, M; Cohen, H; (1996) Second-trimester pregnancy loss is associated with activated C resistance (Editor’s selection: 1997 Year Book of Obstetrics and Gynaecology and selected to be abstracted in the July 1996 issue of Focus and Opinion/Obstetrics and Gynaecology). British journal of haematology , 92 pp. 489-490.

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Abstract

We have investigated whether activated protein C resistance (APCR) is associated with second-trimester miscarriage. The prevalence of APCR was significantly higher amongst women with a history of second-trimester miscarriage (10/50; 20%) compared with either women with a history of first-trimester miscarriages only (4/70; 5.7%) or a control group of parous women with no previous history of pregnancy losses (3/70; 4.3%) (P < 0.02). These results suggest that APCR may be an important mechanism of second-trimester pregnancy loss, possibly related to the increase in intravascular coagulation that occurs during pregnancy.

Type: Article
Title: Second-trimester pregnancy loss is associated with activated C resistance (Editor’s selection: 1997 Year Book of Obstetrics and Gynaecology and selected to be abstracted in the July 1996 issue of Focus and Opinion/Obstetrics and Gynaecology).
Additional information: Rai, R Regan, L Hadley, E Dave, M Cohen, H ENGLAND Br J Haematol. 1996 Feb;92(2):489-90. We have investigated whether activated protein C resistance (APCR) is associated with second-trimester miscarriage. The prevalence of APCR was significantly higher amongst women with a history of second-trimester miscarriage (10/50; 20%) compared with either women with a history of first-trimester miscarriages only (4/70; 5.7%) or a control group of parous women with no previous history of pregnancy losses (3/70; 4.3%) (P < 0.02). These results suggest that APCR may be an important mechanism of second-trimester pregnancy loss, possibly related to the increase in intravascular coagulation that occurs during pregnancy.
Keywords: Abortion, Habitual/*etiology Adult Female Humans Partial Thromboplastin Time Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Second Thrombosis/*complications
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/1331421
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