UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Parkinson's disease and cancer: two wars, one front

Devine, MJ; Plun-Favreau, H; Wood, NW; (2011) Parkinson's disease and cancer: two wars, one front. NAT REV CANCER , 11 (11) 812 - +. 10.1038/nrc3150.

Full text not available from this repository.

Abstract

Parkinson's disease is caused by the premature death of neurons in the midbrain. By contrast, cancer spawns from cells that refuse to die. We would therefore expect their pathogenic mechanisms to be very different. However, recent genetic studies and emerging functional work show that strikingly similar and overlapping pathways are involved in both diseases. We consider these areas of convergence and discuss how insights from one disease can inform us about, and possibly help us to treat, the other.

Type:Article
Title:Parkinson's disease and cancer: two wars, one front
DOI:10.1038/nrc3150
Keywords:RECESSIVE JUVENILE PARKINSONISM, CYCLIN-DEPENDENT KINASE-5, DOPAMINERGIC NEURON LOSS, GENOME-WIDE ASSOCIATION, ALPHA-SYNUCLEIN, GAUCHER-DISEASE, OXIDATIVE STRESS, GLUCOCEREBROSIDASE MUTATIONS, PROTEIN-DEGRADATION, SUBSTANTIA-NIGRA
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Molecular Neuroscience

Archive Staff Only: edit this record