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Early oligodendrocyte progenitor cells in the human fetal telencephalon

Rakic, S; Zecevic, N; (2003) Early oligodendrocyte progenitor cells in the human fetal telencephalon. GLIA , 41 (2) 117 - 127. 10.1002/glia.10140.

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Abstract

Oligodendrocytes, the myelin-producing cells in the central nervous system, represent a large portion of the total number of cells in the human brain. Using cell-specific markers and antibodies to ventral homeodomain transcription factors, NKX2.1 and DLX2, we show here that a subpopulation of early oligodendrocyte progenitor cells (OPCs) in the human telencephalon may originate in the ganglionic eminence (GE). DLX2-labeled OPCs form a well-delineated stream of cells connecting the GE subventricular zone (SVZ) to the cortical intermediate zone through the anterior cortical SVZ. This population of cells is labeled by early OPCs markers, PDGFRalpha, Olig1, and NG2, and not with either neuronal, astrocyte, or late OPCs markers. Intriguingly, numerous CD68(+) microglia/macrophages, nestin(+) neural stem cells, and CD34(+) hematopoietic stem cells (HSCs) are also present in both the GE stream and the cortical SVZ. These cells could be colabeled with DLX2 as well as early OPCs markers. A separate subpopulation of early OPCs, present in the GE and cortical SVZ, did not express either DLX2 or CD68. These findings suggest that different subpopulations of early OPCs, characterized with different sets of transcription factors and cell-specific markers, are present in human forebrain. These subpopulations may have different origins; one may originate in the cortical SVZ, while others may come from the GE and/or outside the CNS as hematopoietic stem cells.

Type: Article
Title: Early oligodendrocyte progenitor cells in the human fetal telencephalon
DOI: 10.1002/glia.10140
Keywords: human brain development, transcription factors, oligodendrocyte lineage, microglia, hematopoietic stem cells, CENTRAL-NERVOUS-SYSTEM, NEURAL STEM-CELLS, MONOCLONAL-ANTIBODIES O1, PDGF ALPHA-RECEPTOR, SONIC HEDGEHOG, BASAL FOREBRAIN, IN-VIVO, CORTICAL INTERNEURONS, TRANSCRIPTION FACTOR, GANGLIONIC EMINENCE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1329682
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