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Role of K-ATP channels in sepsis

Buckley, JF; Singer, M; Clapp, LH; (2006) Role of K-ATP channels in sepsis. CARDIOVASC RES , 72 (2) 220 - 230. 10.1016/j.cardiores.2006.07.011.

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Abstract

Sepsis is an infection-induced inflammatory syndrome responsible for similar to 10% of all deaths worldwide. While pathophysiological mechanisms remain to be fully unravelled, new insights and discoveries are yielding significant improvements in outcome, particularly in the high mortality conditions of shock and multi-organ failure. One potential target is the ATP-sensitive potassium (K-ATP) channel, an ion channel critical to the cardiovascular stress response. Excessive activation of the vascular channel is now recognised as a major cause of hypotension and vascular hyporesponsiveness to catecholamines in septic shock. Some researchers advocate therapeutic blockade of these channels; however, outside the vasculature, channel opening may actually represent a protective mechanism against cellular damage. In this review we critically examine the role of the K-ATP channel in sepsis. (c) 2006 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

Type: Article
Title: Role of K-ATP channels in sepsis
DOI: 10.1016/j.cardiores.2006.07.011
Keywords: K-ATP channel, sepsis, septic shock, vascular hyporeactivity, multi-organ failure, mitochondria, insulin, NITRIC-OXIDE SYNTHASE, SENSITIVE POTASSIUM CHANNELS, VASCULAR SMOOTH-MUSCLE, GENE-RELATED PEPTIDE, INTENSIVE INSULIN THERAPY, CRITICALLY-ILL PATIENTS, BLOOD-GLUCOSE CONTROL, SEPTIC SHOCK, ACTIN CYTOSKELETON, MITOCHONDRIAL DYSFUNCTION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Internal Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: http://discovery.ucl.ac.uk/id/eprint/132854
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