UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Xrx1 controls proliferation and multipotency of retinal progenitors

Casarosa, S; Amato, MA; Andreazzoli, M; Gestri, G; Barsacchi, G; Cremisi, F; (2003) Xrx1 controls proliferation and multipotency of retinal progenitors. MOL CELL NEUROSCI , 22 (1) 25 - 36. 10.1016/S1044-7431(02)00025-8.

Full text not available from this repository.

Abstract

We investigated the function of Xrx1 during Xenopus retinogenesis. Xrx1 overexpression lengthens mitotic activity and ectopically activates the expression of markers of undifferentiated progenitors in the developing retina. We assayed Xrx1 ability to support proliferation with a cell-autonomous mechanism by in vivo lipofection of single retinal progenitors. Xrx1 overexpression increases clonal proliferation while Xrx1 functional inactivation exerts the opposite effect. We also compared the effects of Xrx1 with those of the cyclin-dependent kinase cdk2, a strong mitotic promoter. Despite the similar increase in clonal proliferation displayed by both factors, Xrx1 and cdk2 act differently on retinal cell fate determination. cdk2/cyclinA2 lipofected retinas show a decrease in early-born cell types as ganglion cells and cones and an increase in late-born types such as bipolar neurons. On the contrary, Xrx1 lipofected retinas show no changes in the proportions of the different cell types, thus suggesting a role in supporting multipotency of retinal progenitors. (C) 2003 Elsevier Science (USA). All rights reserved.

Type: Article
Title: Xrx1 controls proliferation and multipotency of retinal progenitors
DOI: 10.1016/S1044-7431(02)00025-8
Keywords: VERTEBRATE NERVOUS-SYSTEM, GROWTH-FACTOR RECEPTOR, CELL-FATE, XENOPUS-RETINA, HOMEOBOX GENE, DEVELOPMENTAL TIMER, ROD PHOTORECEPTORS, GANGLION-CELL, MOUSE RETINA, BHLH GENES
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1327328
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item