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Anal sexually transmitted infections and risk of HIV infection in homosexual men.

Jin, F; Prestage, GP; Imrie, J; Kippax, SC; Donovan, B; Templeton, DJ; Cunningham, A; ... Grulich, AE; + view all (2010) Anal sexually transmitted infections and risk of HIV infection in homosexual men. J Acquir Immune Defic Syndr , 53 (1) pp. 144-149. 10.1097/QAI.0b013e3181b48f33.

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Abstract

BACKGROUND: We examined a range of common bacterial and viral sexually transmitted infections as risk factors for HIV seroconversion in a community-based cohort of HIV-negative homosexual men in Sydney, Australia. METHODS: Detailed information about HIV risk behaviors was collected by interview twice yearly. Participants were tested annually for HIV, anal and urethral gonorrhea and chlamydia, herpes simplex virus types 1 and 2, and syphilis. In addition, they reported annual diagnoses of these conditions and of genital and anal warts. RESULTS: Among 1427 enrolled participants, 53 HIV seroconverters were identified, giving an incidence of 0.78 per 100 person-years. After controlling for number of episodes of insertive and receptive nonseroconcordant unprotected anal intercourse, there were independent associations with anal gonorrhea (adjusted hazard ratio = 7.12, 95% confidence interval: 2.05 to 24.79) and anal warts (hazard ratio = 3.63, 95% confidence interval: 1.62 to 8.14). CONCLUSIONS: Anal gonorrhea and anal warts were independently associated with HIV acquisition. The added HIV prevention value of more frequent screening of the anus to allow early detection and treatment of anal sexually transmitted infections in homosexual men should be considered.

Type: Article
Title: Anal sexually transmitted infections and risk of HIV infection in homosexual men.
Location: United States
DOI: 10.1097/QAI.0b013e3181b48f33
Keywords: Adolescent, Adult, Aged, Australia, Cohort Studies, Follow-Up Studies, HIV Infections, HIV Seropositivity, Homosexuality, Humans, Male, Middle Aged, Risk Factors, Sexual Behavior, Surveys and Questionnaires, Young Adult
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health > Infection and Population Health
URI: http://discovery.ucl.ac.uk/id/eprint/1327153
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