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Role of multiprotein bridging factor 1 in archaea: bridging the domains?

de Koning, B; Blombach, F; Wu, H; Brouns, SJJ; van der Oost, J; (2009) Role of multiprotein bridging factor 1 in archaea: bridging the domains? BIOCHEMICAL SOCIETY TRANSACTIONS , 37 52 - 57. 10.1042/BST0370052.

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Abstract

MGF1 (multiprotein bridging factor 1) is a highly conserved protein in archaea and eukaryotes. It was originally identified as a mediator of the eukaryotic transcription regulator BmFTZ-F1 (Bombyx mori regulator of fushi torazu). MBF1 was demonstrated to enhance transcription by forming a bridge between distinct regulatory DNA-binding proteins and the TATA-box-binding protein. MBF1 consists of two parts: a C-terminal part that contains a highly conserved helix-turn-helix, and an N-terminal part that shows a clear divergence: in eukaryotes, it is a weakly conserved flexible domain, whereas, in archaea, it is a conserved zinc-ribbon domain. Although its function in archaea remains elusive, its function as a transcriptional co-activator has been deduced from thorough studies of several eukaryotic proteins, often indicating a role in stress response. In addition, MBF1 was found to influence translation fidelity in yeast. Genome context analysis of mbf1 in archaea revealed conserved clustering in the crenarchaeal branch together with genes generally involved in gene expression. It points to a role of MBF1 in transcription and/or translation. Experimental data are required to allow comparison of the archaeal MBF1 with its eukaryotic counterpart.

Type: Article
Title: Role of multiprotein bridging factor 1 in archaea: bridging the domains?
Location: Univ St Andrews, St Andrews, SCOTLAND
DOI: 10.1042/BST0370052
Keywords: archaeon, co-activator, endothelial cell differentiation factor 1 (EDF-1), multiprotein bridging factor 1 (MBF1), transcription, translation fidelity, TRANSCRIPTIONAL COACTIVATOR MBF1, BOX-BINDING-PROTEIN, P-LOOP GTPASES, FACTOR-I, SACCHAROMYCES-CEREVISIAE, SECONDARY STRUCTURE, OXIDATIVE STRESS, GENE-EXPRESSION, BOMBYX-MORI, ARABIDOPSIS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1326363
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