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Resistance of three immortalized human hepatocyte cell lines to acetaminophen and N-acetyl-p-benzoquinoneimine toxicity.

McCloskey, P; Edwards, RJ; Tootle, R; Selden, C; Roberts, E; Hodgson, HJ; (1999) Resistance of three immortalized human hepatocyte cell lines to acetaminophen and N-acetyl-p-benzoquinoneimine toxicity. J Hepatol , 31 (5) 841 - 851.

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Abstract

Acetaminophen toxicity in hepatocytes is attributed to generation of the toxic metabolite N-acetyl-p-benzoquinoneimine, leading to depletion of intracellular glutathione, alteration of redox potential and ultimately, cellular necrosis. We aimed to determine the effect of acetaminophen and N-acetyl-p-benzoquinoneimine on three human hepatocyte cell lines HH25, HH29 and HHY41, and for comparison, on primary rat hepatocytes, a cell type that is relatively resistant to acetaminophen-induced toxicity.

Type:Article
Title:Resistance of three immortalized human hepatocyte cell lines to acetaminophen and N-acetyl-p-benzoquinoneimine toxicity.
Location:DENMARK
Language:English
Keywords:Acetaminophen, Animals, Benzoquinones, Cell Line, Transformed, Cells, Cultured, Cytochrome P-450 CYP1A1, Cytochrome P-450 Enzyme System, DNA, Drug Resistance, Glutathione, Humans, Imines, Kinetics, L-Lactate Dehydrogenase, Liver, Male, Mitochondria, Liver, Oxidoreductases, Rats, Rats, Wistar, Serum Albumin

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