McCloskey, P and Edwards, RJ and Tootle, R and Selden, C and Roberts, E and Hodgson, HJ (1999) Resistance of three immortalized human hepatocyte cell lines to acetaminophen and N-acetyl-p-benzoquinoneimine toxicity. J Hepatol , 31 (5) 841 - 851.
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Acetaminophen toxicity in hepatocytes is attributed to generation of the toxic metabolite N-acetyl-p-benzoquinoneimine, leading to depletion of intracellular glutathione, alteration of redox potential and ultimately, cellular necrosis. We aimed to determine the effect of acetaminophen and N-acetyl-p-benzoquinoneimine on three human hepatocyte cell lines HH25, HH29 and HHY41, and for comparison, on primary rat hepatocytes, a cell type that is relatively resistant to acetaminophen-induced toxicity.
|Title:||Resistance of three immortalized human hepatocyte cell lines to acetaminophen and N-acetyl-p-benzoquinoneimine toxicity.|
|Keywords:||Acetaminophen, Animals, Benzoquinones, Cell Line, Transformed, Cells, Cultured, Cytochrome P-450 CYP1A1, Cytochrome P-450 Enzyme System, DNA, Drug Resistance, Glutathione, Humans, Imines, Kinetics, L-Lactate Dehydrogenase, Liver, Male, Mitochondria, Liver, Oxidoreductases, Rats, Rats, Wistar, Serum Albumin|
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