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EXPRESSION OF HEPATOCYTE GROWTH-FACTOR MESSENGER-RNA, AND C-MET MESSENGER-RNA (HEPATOCYTE GROWTH-FACTOR RECEPTOR) IN HUMAN LIVER-TUMORS

SELDEN, C; FARNAUD, S; DING, SF; HABIB, N; FOSTER, C; HODGSON, HJF; (1994) EXPRESSION OF HEPATOCYTE GROWTH-FACTOR MESSENGER-RNA, AND C-MET MESSENGER-RNA (HEPATOCYTE GROWTH-FACTOR RECEPTOR) IN HUMAN LIVER-TUMORS. J HEPATOL , 21 (2) 227 - 234.

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Abstract

We have quantified mRNA for the hepatocyte growth factor and its putative receptor the c-met proto-oncogene protein product, in a series of human primary and secondary liver tumours and adjacent non-neoplastic liver. In all hepatocellular cancers, hepatocyte growth factor 6 kb mRNA expression was less (mean 23.93%+/-6.33% S.E.M. n=7) in the tumours than in the adjacent normal liver. Both relative over- and under-expression of c-met transcripts were found in tumour tissue compared to non-neoplastic liver. Thus hepatocellular cancer tissue does not over-express mRNA for hepatocyte growth factor, though this growth factor might play a role in hyperproliferative states leading to liver cancer. (C) Journal of Hepatology.

Type:Article
Title:EXPRESSION OF HEPATOCYTE GROWTH-FACTOR MESSENGER-RNA, AND C-MET MESSENGER-RNA (HEPATOCYTE GROWTH-FACTOR RECEPTOR) IN HUMAN LIVER-TUMORS
Keywords:HEPATOMA, HUMAN GROWTH FACTOR, SCATTER FACTOR, TYROSINE KINASE RECEPTOR, FACTOR HEPATOPOIETIN-A, FAT-STORING CELLS, TYROSINE KINASE, EPITHELIAL-CELLS, DNA-SYNTHESIS, FACTOR-HGF, HEPATOCELLULAR-CARCINOMA, PARTIAL-HEPATECTOMY, GENE AMPLIFICATION, MOLECULAR-CLONING

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