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Functional genomics assays to study CFTR traffic and ENaC function.

Almaça, J; Dahimène, S; Appel, N; Conrad, C; Kunzelmann, K; Pepperkok, R; Amaral, MD; (2011) Functional genomics assays to study CFTR traffic and ENaC function. Methods Mol Biol , 742 pp. 249-264. 10.1007/978-1-61779-120-8_15.

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Abstract

As several genomes have been sequenced, post-genomic approaches like transcriptomics and proteomics, identifying gene products differentially expressed in association with a given pathology, have held promise both of understanding the pathways associated with the respective disease and as a fast track to therapy. Notwithstanding, these approaches cannot distinguish genes and proteins with mere secondary pathological association from those primarily involved in the basic defect(s). New global strategies and tools identifying gene products responsible for the basic cellular defect(s) in CF pathophysiology currently being performed are presented here. These include high-content screens to determine proteins affecting function and trafficking of CFTR and ENaC.

Type: Article
Title: Functional genomics assays to study CFTR traffic and ENaC function.
Location: United States
DOI: 10.1007/978-1-61779-120-8_15
Keywords: Cell Line, Tumor, Cystic Fibrosis, Cystic Fibrosis Transmembrane Conductance Regulator, Epithelial Cells, Epithelial Sodium Channel Blockers, Epithelial Sodium Channels, Fluorescence, Gene Silencing, Genomics, High-Throughput Screening Assays, Humans, Microscopy, Confocal, Mutation, Plasmids, Protein Transport, RNA, Small Interfering, Sequence Deletion, Spectrometry, Fluorescence, Transfection
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/1325270
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