UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

ANTIPHOSPHOLIPID ANTIBODIES AND BETA-2-GLYCOPROTEIN-I IN 500 WOMEN WITH RECURRENT MISCARRIAGE - RESULTS OF A COMPREHENSIVE SCREENING APPROACH

RAI, RS; REGAN, L; CLIFFORD, K; PICKERING, W; DAVE, M; MACKIE, I; MCNALLY, T; (1995) ANTIPHOSPHOLIPID ANTIBODIES AND BETA-2-GLYCOPROTEIN-I IN 500 WOMEN WITH RECURRENT MISCARRIAGE - RESULTS OF A COMPREHENSIVE SCREENING APPROACH. HUM REPROD , 10 (8) 2001 - 2005.

Full text not available from this repository.

Abstract

Five hundred consecutive women (median age 33 years; range 19-45) with a history of recurrent miscarriage (median 4; range 3-16) were screened for the presence of antiphospholipid antibodies (APA)-lupus anticoagulant (LA) and/or anticardiolipin antibodies (ACA). The prevalence of persistently positive tests for LA was 9.6% and for immunoglobulin G (IgG) and immunoglobulin M (IgM) ACA was 3.3 and 2.2% respectively. Only seven women (1.4%) were LA and ACA positive. Repeat testing, after an interval of at least 8 weeks, demonstrated that only 65.7% of LA positive, 36.6% IgG ACA positive and 36.0% IgM ACA positive women on initial testing had a second positive test result. The dilute Russell's viper venom time detected the LA significantly more often than either the activated partial thromboplastin time or the kaolin clotting time (P < 0.001). There was no difference in the gestation of previous miscarriages between APA positive and APA negative women. There was no difference in the plasma beta(2)-glycoprotein-I concentrations between APA positive and APA negative women with miscarriages and normal women. All women with a history of recurrent miscarriage should be tested for the presence of both LA and ACA. A second confirmatory test should be performed in those with an initial positive test result.

Type: Article
Title: ANTIPHOSPHOLIPID ANTIBODIES AND BETA-2-GLYCOPROTEIN-I IN 500 WOMEN WITH RECURRENT MISCARRIAGE - RESULTS OF A COMPREHENSIVE SCREENING APPROACH
Keywords: ANTIPHOSPHOLIPID ANTIBODIES, BETA(2)-GLYCOPROTEIN-I, EPIDEMIOLOGY, RECURRENT MISCARRIAGE, SYSTEMIC LUPUS-ERYTHEMATOSUS, ANTICARDIOLIPIN ANTIBODIES, ANTICOAGULANT ACTIVITY, FETAL DEATH, PROTEIN C, INHIBITION, ABORTION, THROMBOSIS, PREVALENCE, PREGNANCY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/1324285
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item