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THE SPINAL AND PERIPHERAL ROLES OF BRADYKININ AND PROSTAGLANDINS IN NOCICEPTIVE PROCESSING IN THE RAT

CHAPMAN, V; DICKENSON, AH; (1992) THE SPINAL AND PERIPHERAL ROLES OF BRADYKININ AND PROSTAGLANDINS IN NOCICEPTIVE PROCESSING IN THE RAT. EUR J PHARMACOL , 219 (3) 427 - 433.

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Abstract

The effect of peripheral and intrathecal administration of the bradykinin B2 receptor antagonist HOE140 and the non-steroidal anti-inflammatory drug indomethacin were studied on the response of dorsal horn nociceptive neurones to formalin in the anaesthetized rat. Peripheral pretreatment with HOE14() reduced both phases of the formalin response whereas subcutaneous administration of indomethacin (5 mg/kg) reduced only the second phase. Pre-treatment with intrathecal HOE140 resulted in a dose-dependent reduction of the second phase whereas a high dose (500-mu-g) intrathecal indomethacin reduced both phases of the response. Bradykinin plays a role in peripheral nociception during the first and second phase of the response whereas the prostaglandins are only involved during the second phase. The converse is true centrally, the prostaglandins appear to be involved in both phases of the formalin response whereas bradykinin only plays a central role during the second phase of the response.

Type: Article
Title: THE SPINAL AND PERIPHERAL ROLES OF BRADYKININ AND PROSTAGLANDINS IN NOCICEPTIVE PROCESSING IN THE RAT
Keywords: NOCICEPTION, SPINAL CORD, FORMALIN, BRADYKININ, PROSTAGLANDINS, (RAT), ASPIRIN-LIKE DRUGS, DORSAL HORN NEURONS, FORMALIN-INDUCED ACTIVITY, CHEMICAL NOCICEPTION, ANTAGONISTS, MECHANISM, PAIN, POTENT, INHIBITION, ANALGESIA
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/132307
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