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THE COMBINATION OF NMDA ANTAGONISM AND MORPHINE PRODUCES PROFOUND ANTINOCICEPTION IN THE RAT DORSAL HORN

CHAPMAN, V; DICKENSON, AH; (1992) THE COMBINATION OF NMDA ANTAGONISM AND MORPHINE PRODUCES PROFOUND ANTINOCICEPTION IN THE RAT DORSAL HORN. BRAIN RES , 573 (2) 321 - 323.

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Abstract

Dorsal horn nociceptive neurones exhibit wind up, a frequency dependent potentiation of their responses to repeated C-fibre stimulation. Intrathecal morphine (5-mu-g) significantly reduces the initial responses of the neurones but not wind up whereas the reverse is true for N-methyl-D-aspartate (NMDA) antagonists. The combination of intrathecal morphine (5-mu-g) and 7-chlorokynurenate (2.5-mu-g), an antagonist at the glycine site of the NMDA receptor, abolishes both the input and wind up of these neurones.

Type: Article
Title: THE COMBINATION OF NMDA ANTAGONISM AND MORPHINE PRODUCES PROFOUND ANTINOCICEPTION IN THE RAT DORSAL HORN
Keywords: N-METHYL-D-ASPARTATE RECEPTOR, NOCICEPTION, MORPHINE, SPINAL CORD, WIND UP, C-FIBER RESPONSE, INTRATHECAL MORPHINE, NOCICEPTIVE NEURONS, SPINAL-CORD, P RELEASE, RECEPTOR, GLYCINE, ANALGESICS, SUBSTANCE, COMPLEX, SITE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/132305
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