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THE ANTINOCICEPTIVE ACTIONS OF DEXMEDETOMIDINE ON DORSAL HORN NEURONAL RESPONSES IN THE ANESTHETIZED RAT

SULLIVAN, AF; KALSO, EA; MCQUAY, HJ; DICKENSON, AH; (1992) THE ANTINOCICEPTIVE ACTIONS OF DEXMEDETOMIDINE ON DORSAL HORN NEURONAL RESPONSES IN THE ANESTHETIZED RAT. EUR J PHARMACOL , 215 (1) 127 - 133.

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Abstract

The actions of the selective alpha-2-adrenoceptor agonist dexmedetomidine were examined on the nociceptive C and innocuous A-beta fibre-evoked responses of dorsal horn neurones to transcutaneous electrical stimulation in the intact anaesthetized rat. C fibre-evoked responses were dose dependently reduced by intrathecal dexmedetomidine - to a maximum 86 +/- 6% inhibition by 10-mu-g of the agonist. The ED50 for inhibition of C fibre responses was estimated to be 2.5-mu-g. A-beta-evoked responses were inhibited to a lesser degree - a maximum 54 +/- 8% inhibition after 10-mu-g dexmedetomidine. The antinociceptive effects of dexmedetomidine were reversed by the alpha-2-adrenoceptor antagonist atipamezole and the opioid antagonist naloxone. The results are discussed with reference to adrenergic and opioid mechanisms in the spinal cord.

Type: Article
Title: THE ANTINOCICEPTIVE ACTIONS OF DEXMEDETOMIDINE ON DORSAL HORN NEURONAL RESPONSES IN THE ANESTHETIZED RAT
Keywords: ANTINOCICEPTION, SPINAL CORD, DORSAL HORN NEURONS, ALPHA-2-ADRENOCEPTOR AGONISTS, DEXMEDETOMIDINE, OPIOIDS, SPINAL-CORD, ALPHA-2-ADRENOCEPTOR AGONIST, SELECTIVE-INHIBITION, NOCICEPTIVE NEURONS, BINDING-SITES, NORADRENALINE, STIMULATION, MEDETOMIDINE, CLONIDINE, MORPHINE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/132303
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