UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

EVIDENCE FOR THE INVOLVEMENT OF THE MU-OPIOID BUT NOT DELTA-OPIOID RECEPTOR SUBTYPE IN THE SYNERGISTIC INTERACTION BETWEEN OPIOID AND ALPHA-2 ADRENERGIC ANTINOCICEPTION IN THE RAT SPINAL-CORD

SULLIVAN, AF; KALSO, EA; MCQUAY, HJ; DICKENSON, AH; (1992) EVIDENCE FOR THE INVOLVEMENT OF THE MU-OPIOID BUT NOT DELTA-OPIOID RECEPTOR SUBTYPE IN THE SYNERGISTIC INTERACTION BETWEEN OPIOID AND ALPHA-2 ADRENERGIC ANTINOCICEPTION IN THE RAT SPINAL-CORD. NEUROSCI LETT , 139 (1) 65 - 68.

Full text not available from this repository.

Abstract

The interaction between the spinal antinociceptive effects of selective mu or delta-opioid agonists morphine and DSTBULET (Tyr-D-Ser(OtBu)-Gly-Phe-Leu-Thr), respectively, and the selective alpha-2 adrenergic agonist dexmedetomidine was examined on convergent dorsal horn neuronal responses in the intact anaesthetized rat. The coadministration of intrathecal morphine (0.5-mu-g, 2.5-mu-g) and dexmedetomidine (0.5-mu-g) produced a greater than additive inhibition of C fibre-evoked responses. Inhibitions were reversed by either the opioid antagonist naloxone or the alpha-2 adrenergic antagonist atipamezole. The coadministration of intrathecal DSTBULET (1-mu-g, 2.5-mu-g) and dexmedetomidine did not result in a supra-additive inhibition of C fibre-evoked responses. The results suggest that mu rather than delta-opioid receptors are involved in the synergism of spinal opioid and alpha-2 adrenergic antinociception.

Type: Article
Title: EVIDENCE FOR THE INVOLVEMENT OF THE MU-OPIOID BUT NOT DELTA-OPIOID RECEPTOR SUBTYPE IN THE SYNERGISTIC INTERACTION BETWEEN OPIOID AND ALPHA-2 ADRENERGIC ANTINOCICEPTION IN THE RAT SPINAL-CORD
Keywords: MU-OPIOID, DELTA-OPIOID, ALPHA-2 ADRENERGIC, MORPHINE, DSTBULET, DEXEMEDETOMIDINE, DORSAL HORN NEURON, SPINAL ANTINOCICEPTION, DORSAL-HORN, NOCICEPTIVE NEURONS, LOCUS COERULEUS, RESPONSES, MORPHINE, POTENTIATION, MECHANISMS, INHIBITION, CLONIDINE, AFFERENTS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/132302
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item