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ELECTROPHYSIOLOGICAL EVIDENCE FOR A ROLE OF NITRIC-OXIDE IN PROLONGED CHEMICAL NOCICEPTION IN THE RAT

HALEY, JE; DICKENSON, AH; SCHACHTER, M; (1992) ELECTROPHYSIOLOGICAL EVIDENCE FOR A ROLE OF NITRIC-OXIDE IN PROLONGED CHEMICAL NOCICEPTION IN THE RAT. NEUROPHARMACOLOGY , 31 (3) 251 - 258.

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Abstract

The role of nitric oxide in the periphery and the spinal cord, during acute electrically-evoked and prolonged chemically-evoked nociceptive stimulation, was investigated in rats anaesthetised with halothane. The responses of single dorsal horn neurones to electrically-evoked A-beta-fibre and C fibre inputs were reduced by topical application (directly onto the spinal cord) of both the nitric oxide inhibitor, nitro-L-arginine methyl ester (L-NAME; 500-1500-mu-g) and the precursor of nitric oxide, L-arginine (4500-mu-g). Administration of L-NAME, either directly into the receptive field (500-1500-mu-g) or intravenously (10-100 mg/kg) had little or no effect on the acute electrically-evoked activity. Intravenous injection of L-NAME, administered 40 min prior to injection of formalin, significantly reduced the prolonged second peak of firing, with only a small effect on the short-duration first peak. Administration of L-NAME, directly into the site of injection of formalin, as a 10 min pretreatment, significantly reduced the second but not the first peak of the response. Topical application of L-NAME onto the spinal cord, as a 30 min pretreatment, significantly reduced both the first and second peaks of the response. This inhibition was not reversed by the coadministration of L-arginine, which was inhibitory by itself. Thus, nitric oxide may be involved, in a complex way, in nociceptive events both in the periphery and within the spinal cord.

Type: Article
Title: ELECTROPHYSIOLOGICAL EVIDENCE FOR A ROLE OF NITRIC-OXIDE IN PROLONGED CHEMICAL NOCICEPTION IN THE RAT
Keywords: NITRIC OXIDE, NOCICEPTION, FORMALIN, L-ARGININE, CULTURED ENDOTHELIAL-CELLS, SOLUBLE GUANYLATE-CYCLASE, RELAXING FACTOR, FORMALIN TEST, DORSAL HORN, L-ARGININE, SMOOTH-MUSCLE, STIMULATION, BRADYKININ, RECEPTORS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/132297
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