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SPINAL LOCAL-ANESTHETIC ACTIONS ON AFFERENT EVOKED-RESPONSES AND WIND-UP OF NOCICEPTIVE NEURONS IN THE RAT SPINAL-CORD - COMBINATION WITH MORPHINE PRODUCES MARKED POTENTIATION OF ANTINOCICEPTION

FRASER, HM; CHAPMAN, V; DICKENSON, AH; (1992) SPINAL LOCAL-ANESTHETIC ACTIONS ON AFFERENT EVOKED-RESPONSES AND WIND-UP OF NOCICEPTIVE NEURONS IN THE RAT SPINAL-CORD - COMBINATION WITH MORPHINE PRODUCES MARKED POTENTIATION OF ANTINOCICEPTION. PAIN , 49 (1) 33 - 41.

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Abstract

Lignocaine was tested either alone or in combination with a low dose of morphine by intrathecal administration on the C- and A-beta evoked responses of nociceptive neurones in the dorsal horn of the halothane-anaesthetized rat. In addition the effect of prilocaine was compared to lignocaine. The effects of lignocaine on wind-up, a frequency-dependent increase in the responses of the cells produced by repeated C-fibre stimulation was also tested.Lignocaine produced dose-dependent inhibitions of the C-, A-delta and A-beta evoked responses of the cells which became more selective for the noxious evoked responses as the dose increased. The effective doses corresponded well to those used clinically. Wind-up was also decreased by lignocaine.In combination with a low dose of morphine, threshold doses of lignocaine produced a highly marked potentiation of the inhibitions of the C-fibre evoked responses compared to either agent alone. No potentiation of the inhibitions of the A-beta responses was observed. The potentiated inhibitory effects on the C-fibre responses were rapidly reversed by intrathecal naloxone.The finding that spinal local anaesthetic and morphine potentiate markedly to reduce spinal nociception is discussed both in terms of mechanisms of action of the agents and their clinical application.

Type: Article
Title: SPINAL LOCAL-ANESTHETIC ACTIONS ON AFFERENT EVOKED-RESPONSES AND WIND-UP OF NOCICEPTIVE NEURONS IN THE RAT SPINAL-CORD - COMBINATION WITH MORPHINE PRODUCES MARKED POTENTIATION OF ANTINOCICEPTION
Keywords: NOCICEPTION, SPINAL LOCAL ANESTHESIA, MORPHINE, C-FIBERS, NMDA RECEPTOR ANTAGONISTS, DORSAL HORN, INTRATHECAL MORPHINE, OPIOID RECEPTORS, PAIN, PHARMACOLOGY, INVOLVEMENT, ANALGESIA, TRANSMISSION, BUPIVACAINE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/132296
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