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B cell lipid presentation controls the homeostasis and immunoregulatory function of iNKT cells in healthy controls but not in SLE patients. Analysis of a cohort of patients before and after rituximab treatment

Abdel-Gadir, A.; (2011) B cell lipid presentation controls the homeostasis and immunoregulatory function of iNKT cells in healthy controls but not in SLE patients. Analysis of a cohort of patients before and after rituximab treatment. Doctoral thesis, UCL (University College London).

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Abstract

B cells are characteristically the main ,er0tagonists in the pathogenesis of systemic lupus erythematosus (SLE) and its clinical manifestations. It is known that iNKT cells may interact with B cells to steer the production of autoantibodies in SLE, whether CD1 d-mediated lipidantigen presentation by B cells maintains invariant natural killer T (iNKT) cells in vivo remains unclear. I demonstrate that B cells are crucial for iNKT cell expansion in healthy individuals. SLE patients have reduced iNKT cell numbers, fail to expand and produce TH1like cytokines. We use confocal microscopy to visualise increased CD1 d aggregation in SLE B cells compared to healthy B cells. Thus, "healthy"antigen-presenting B cells are pivotal for the physiological maintenance of iNKT cells.

Type:Thesis (Doctoral)
Title:B cell lipid presentation controls the homeostasis and immunoregulatory function of iNKT cells in healthy controls but not in SLE patients. Analysis of a cohort of patients before and after rituximab treatment
Language:English
Additional information:Permission for digitisation not received
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)

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