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T cryptantigen activation is associated with advanced necrotizing enterocolitis

Hall, N; Ong, EGP; Ade-Ajayi, N; Fasoli, L; Ververidis, M; Kiely, EM; Drake, DP; ... Pierro, A; + view all (2002) T cryptantigen activation is associated with advanced necrotizing enterocolitis. In: JOURNAL OF PEDIATRIC SURGERY. (pp. 791 - 793). W B SAUNDERS CO

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Background/Purpose: Thomsen-Friedenreich cryptanligen activation (TCA) exposes neonates with necrotizing enterocolitis NEC to the risk of hemolysis after transfusion of blood products. The authors aimed to determine the prevalence of TCA in neonates with NEC and to correlate TCA with severity of disease and outcome.Methods: One hundred four neonates with NEC were tested for TCA on admission. Patients with TCA requiring transfusion were given packed red cells, low-titer anti-T fresh frozen plasma, and washed platelets to avoid hemolysis.Results: Twenty-three infants had TCA, and 96% of these had stage III disease. The incidence of TCA was significantly higher in infants with stage III disease compared with those with stage II (30% v 4%; P < .01). A total of 91% of infants with TCA required laparotomy compared with 81% of those with no activation. At laparotomy, widespread disease was more common in the TCA group (71% v 55%). TCA did not significantly increase mortality rate (TCA, 39% v no TCA, 28%); this may reflect the transfusion policy of our unit.Conclusions: Twenty-two percent of neonates with NEC referred to our unit had TCA. There is an association between TCA and advanced NEC. Screening of neonates with advanced NEC for TCA is advised to identify those at risk of hematologic complications. Copyright 2002 Elsevier Science (USA). All rights reserved.

Type: Proceedings paper
Title: T cryptantigen activation is associated with advanced necrotizing enterocolitis
Event: 33rd Annual Meeting of the Canadian-Association-of-Paediatric-Surgeons
Dates: 2001
DOI: 10.1053/jpsu.2002.32289
Keywords: T crypt antigen activation, necrotizing enterocolitis, ANTIGEN, TRANSFUSION, HEMOLYSIS
URI: http://discovery.ucl.ac.uk/id/eprint/1322148
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