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Parkinson's Disease and alpha-Synuclein Expression

Devine, MJ; Gwinn, K; Singleton, A; Hardy, J; (2011) Parkinson's Disease and alpha-Synuclein Expression. MOVEMENT DISORD , 26 (12) 2160 - 2168. 10.1002/mds.23948.

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Abstract

Genetic studies of Parkinson's disease over the last decade or more have revolutionized our understanding of this condition. alpha-Synuclein was the first gene to be linked to Parkinson's disease, and is arguably the most important: the protein is the principal constituent of Lewy bodies, and variation at its locus is the major genetic risk factor for sporadic disease. Intriguingly, duplications and triplications of the locus, as well as point mutations, cause familial disease. Therefore, subtle alterations of alpha-synuclein expression can manifest with a dramatic phenotype. We outline the clinical impact of alpha-synuclein locus multiplications, and the implications that this has for Parkinson's disease pathogenesis. Finally, we discuss potential strategies for disease-modifying therapies for this currently incurable disorder. (C) 2011 Movement Disorder Society

Type:Article
Title:Parkinson's Disease and alpha-Synuclein Expression
DOI:10.1002/mds.23948
Keywords:Parkinsonism, genetics, alpha-synuclein, MULTIPLE SYSTEM ATROPHY, LEWY BODY, IN-VIVO, SNCA DUPLICATION, GENE DUPLICATION, MOUSE MODEL, NEURODEGENERATIVE DISEASE, DOPAMINERGIC-NEURONS, LOCUS TRIPLICATION, MESSENGER-RNA
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Molecular Neuroscience

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