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Fluorescence lifetime optical tomography in weakly scattering media in the presence of highly scattering inclusions

Soloviev, VY; Arridge, SR; (2011) Fluorescence lifetime optical tomography in weakly scattering media in the presence of highly scattering inclusions. J OPT SOC AM A , 28 (7) 1513 - 1523.

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Abstract

We consider the problem of fluorescence lifetime optical tomographic imaging in a weakly scattering medium in the presence of highly scattering inclusions. We suggest an approximation to the radiative transfer equation, which results from the assumption that the transport coefficient of the scattering media differs by an order of magnitude for weakly and highly scattering regions. The image reconstruction algorithm is based on the variational framework and employs angularly selective intensity measurements. We present numerical simulation of light scattering in a weakly scattering medium that embeds highly scattering objects. Our reconstruction algorithm is verified by recovering optical and fluorescent parameters from numerically simulated datasets. (C) 2011 Optical Society of America

Type:Article
Title:Fluorescence lifetime optical tomography in weakly scattering media in the presence of highly scattering inclusions
Keywords:PROJECTION TOMOGRAPHY, 3-DIMENSIONAL RECONSTRUCTION, PROPAGATION, MICROSCOPY, INVERSE, NUCLEI, TOOL
UCL classification:UCL > School of BEAMS > Faculty of Engineering Science > Computer Science

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