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Antimicrobial activity of polyurethane embedded with methylene blue, toluidene blue and gold nanoparticles against Staphylococcus aureus; illuminated with white light

Naik, AJT; Ismail, S; Kay, C; Wilson, M; Parkin, IP; (2011) Antimicrobial activity of polyurethane embedded with methylene blue, toluidene blue and gold nanoparticles against Staphylococcus aureus; illuminated with white light. MATER CHEM PHYS , 129 (1-2) 446 - 450. 10.1016/j.matchemphys.2011.04.040.

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Abstract

Polyurethane polymer sheets were embedded with methylene blue (MB), toluidine blue (TBO) and 2 nm gold nanoparticles by a swell-shrink encapsulation process using an acetone water mixture. The polymers were characterised by IR, UV-vis, SEM/WDX and mechanical testing. The dye impregnated polymers were potent at killing suspensions of Staphylococcus aureus under white illumination with a hospital light source (2000 lux) showing a 2.8 log(10) kill (MB) and a 4.3 log(10) kill (TBO) compared to controls when exposed to 24 h of illumination. Notably the incorporation of gold nanoparticles with the dyes enhanced the observed kill to 3.8 log(10) (MB) and 4.8 log(10) (TBO). This is the first time that a derivatised polyurethane polymer used in catheters has been shown to be effective in killing bacteria using white light illumination. (C) 2011 Elsevier B.V. All rights reserved.

Type:Article
Title:Antimicrobial activity of polyurethane embedded with methylene blue, toluidene blue and gold nanoparticles against Staphylococcus aureus; illuminated with white light
DOI:10.1016/j.matchemphys.2011.04.040
Keywords:Polymer, Biomaterial, Antimicrobial, Methylene blue, Toluidene blue, Nanogold, CATHETER-RELATED INFECTIONS, GRAM-NEGATIVE BACTERIA, PHOTODYNAMIC THERAPY, BLOOD COMPONENTS, LETHAL PHOTOSENSITIZATION, MICROBIAL INFECTIONS, SINGLET OXYGEN, PHOTODECONTAMINATION, INACTIVATION, PREVENTION
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Structural and Molecular Biology
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Microbial Diseases
UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry

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