An efficient asymmetric synthesis of the potent beta-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity.
3953 - 3954.
A highly efficient, practical and. flexible two-step asymmetric synthesis of the beta(2)-selective beta-blocker ICI 118,551 is reported, allowing an unambiguous determination of the dependency of biological activity with optical activity, revealing the S,S-enantiomer to be the most potent.
|Title:||An efficient asymmetric synthesis of the potent beta-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity|
|Keywords:||PROTEIN-COUPLED RECEPTOR, CRYSTAL-STRUCTURE, RESOLUTION, SELECTIVITY, EPOXIDATION, ANTAGONISTS|
|UCL classification:||UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of BEAMS
UCL > School of BEAMS > Faculty of Maths and Physical Sciences
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