Baker, JR and Hothersall, JD and Fitzmaurice, RJ and Tucknott, M and Vinter, A and Tinker, A and Caddick, S (2010) An efficient asymmetric synthesis of the potent beta-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity. CHEM COMMUN , 46 (22) 3953 - 3954. 10.1039/c0cc00142b.
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Abstract
A highly efficient, practical and. flexible two-step asymmetric synthesis of the beta(2)-selective beta-blocker ICI 118,551 is reported, allowing an unambiguous determination of the dependency of biological activity with optical activity, revealing the S,S-enantiomer to be the most potent.
| Type: | Article |
|---|---|
| Title: | An efficient asymmetric synthesis of the potent beta-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity |
| DOI: | 10.1039/c0cc00142b |
| Keywords: | PROTEIN-COUPLED RECEPTOR, CRYSTAL-STRUCTURE, RESOLUTION, SELECTIVITY, EPOXIDATION, ANTAGONISTS |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry UCL > VP Enterprise |
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