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The selective interactions and functions of regulators of G-protein signalling

Tinker, A; (2006) The selective interactions and functions of regulators of G-protein signalling. SEMIN CELL DEV BIOL , 17 (3) 377 - 382. 10.1016/j.semcdb.2006.03.007.

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Abstract

There is accumulating evidence that regulators of G-protein signalling (RGS) can have roles in signal transduction that are not related to GAP activity. Furthermore, RGSs have much more selective effects in vivo than might be anticipated from their behaviour in in vitro assays. I discuss the molecular mechanisms by which these phenomena might be explained including specific interactions between the RGS and G-protein coupled receptor, G-protein and effector. (c) 2006 Published by Elsevier Ltd.

Type:Article
Title:The selective interactions and functions of regulators of G-protein signalling
DOI:10.1016/j.semcdb.2006.03.007
Keywords:regulator of G-protein signalling, G-protein alpha subunit, G-protein gated K+ channel, G-protein coupled receptor, HETEROTRIMERIC G-PROTEINS, GTPASE ACCELERATING PROTEIN, MUSCARINIC M2 RECEPTORS, GATED K+ CHANNEL, RGS PROTEINS, POTASSIUM CHANNEL, LIVING CELLS, ALPHA-SUBUNITS, SACCHAROMYCES-CEREVISIAE, DEPENDENT RELAXATION
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)

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