UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Albumin: not just a plasma expander

Davies, NA; Garcia, R; Proven, A; Jalan, R; (2011) Albumin: not just a plasma expander. In: Gerbes, AL, (ed.) Ascites, Hyponatremia and Hepatorenal Syndrome: Progress in Treatment. (40 - 51). Karger: Basel.

Full text not available from this repository.

Abstract

Human serum albumin is important for health and normal metabolic function. It comprises over half of the extracellular protein in blood and is the main regulator of plasma oncotic pressure. Traditionally, its main use has been as a volume expansion agent. Albumin undertakes a wide variety of transport functions and is essential for carrying metabolic products to the liver for metabolism and excretion. Due to its redox- active properties, it also acts as a first line of defence against pro- oxidant and free radical injury. In subjects with liver disease its concentration is reduced, an effect that is further compounded by studies that demonstrate that the remaining protein is functionally impaired. This lack of metabolic function most likely contributes to exacerbation of the disease processes. Administration of albumin to both patients with liver disease, and for a wide variety of other indications, shows beneficial effects that go far beyond simple fluid resuscitation.

Type: Book chapter
Title: Albumin: not just a plasma expander
Keywords: Albumin, Liver disease, cirrhosis, volume expander
URI: http://discovery.ucl.ac.uk/id/eprint/1320135
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item