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Bromopyridazinedione-mediated protein and peptide bioconjugation

Chudasama, V; Smith, MEB; Schumacher, FF; Papaioannou, D; Waksman, G; Baker, JR; Caddick, S; (2011) Bromopyridazinedione-mediated protein and peptide bioconjugation. Chemical Communications , 47 (31) 8781 - 8783. 10.1039/c1cc12807h. Green open access

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Abstract

Bromopyridazinedione-mediated bioconjugation to a cysteine containing protein and a disulfide containing peptide is described. The conjugates are cleavable in an excess of thiol, including cytoplasmically-relevant concentrations of glutathione, and show a high level of hydrolytic stability. The constructs have the potential for four points of chemical attachment.

Type: Article
Title: Bromopyridazinedione-mediated protein and peptide bioconjugation
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c1cc12807h
Publisher version: http://dx.doi.org/10.1039/c1cc12807h
Language: English
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Structural and Molecular Biology
UCL > School of BEAMS
UCL > School of BEAMS > Faculty of Maths and Physical Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/1319804
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